Monique Smalls scored a game-high 14 points on Sunday.
Junior Kelsi Baker and senior Chynna Brown added nine points each while senior Casey Morris had seven and senior Christine Hyde tacked on six and a game-high 10 rebounds.
The win marked the seventh consecutive home opening win for head coach Kristy Curry, who won her 290th game overall. Tech improved to 35-3 all-time in home openers.
"I loved our execution and our ball reversal and the way we shared the ball," Curry said. "Any time you have 15 assists to seven turnovers and have a two-to-one ratio -- you have to be pleased. We did a great job of sharing the basketball today."
Tech (2-1) shot just 23 percent in the opening 10 minutes of the first half and found itself tied at 8-8 before finding a groove that carried on over into the second half.
Brown, who sat out of the starting lineup along with Morris for the first time this season, hit a 3-pointer from the corner to ignite a 16-4 run that gave the Lady Raiders a 24-12 lead at the break.
The run would carry over through halftime as Hyde got in on the action with a rebound and putback to open the second half, followed by back-to-back 3-pointers by senior Mary Bokenkamp and Brown. Smalls hit her second trey at the 13:28 mark to give Tech its largest lead at 37-14 - marking a 29-6 run over a 14-minute span.
"We just said keep shooting because we knock `em down in practice, we shoot the lights out in practice," Hyde said. "So we just keep shooting because it's going to go down. You get in the gym and practice everyday. I can't even tell you how much shooting we did in the offseason. So I was confident in every single one of them to shoot the ball."
Once again it was a relentless defense that helped pave the way for the offensive success on the floor.
Lipscomb (0-3) gave up 23 turnovers while Tech, who leads the Big 12 in steals, had nine on Sunday -- including four from Morris that resulted in 28 points.
Tech now turns its attention to this weekend's Basketball Travelers Invitational, where it will play host to Southern Utah (6 p.m., Friday), Nicholls State (Noon, Saturday), and New Orleans (2 p.m., Sunday).